Host–Guest Inclusion Complexes of Essential Oils with Strong Antibacterial and Antifungal Features in Beta-Cyclodextrin for Solid-State Pharmaceutical Applications

Essential oils are widely recognized as natural alternatives to pharmaceutical antibacterial and antifungal agents. With respect standard pharmaceutics, the advantages of essential their (i) low production costs, (ii) lack chemical biochemical drawbacks that intrinsic synthetic process (iii) good tolerance by humans. On other hand, liquid nature poses concerns about actual application in different therapeutic issues regarding persistence ability control or prolong drug release. In this study, two from oregano winter savory showing features were complexed a solid state with beta-cyclodextrin. Host–guest inclusion complexes characterized using FT-IR spectroscopy, ESI-MS GC-MS techniques. Manyfold terpenic non-terpenic components could be observed unambiguously identified being included inside carbohydrate hosts. Many them provided specific biocidal action. Indeed, oil host–guest products tested against Candida species an S. aureus reference strain, effectively maintained performances. Solid-state tablets embedded polyvinylpyrrolidone obtained. These results pave way for solid-state treatments.